Design, Synthesis, and Structural Analysis of d,l-Mixed Polypyrrolinones. 1. From Nonpeptide Peptidomimetics to Nanotubes
文摘
To expand the potential conformational space available to the polypyrroline structural motif, an open chain, d,l-alternating hexapyrrolinone was designed and synthesized. Structural studies, including solution NMR and X-ray crystallographic analysis, revealed that the hexapyrrolinone adopts a turn conformation both in solution and in the solid state, with aggregation in solution and a nanotube-like quaternary structure in the crystal.