Design, Synthesis, and Structural Analysis of d,l-Mixed Polypyrrolinones. 1. From Nonpeptide Peptidomimetics to Nanotubes

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• 作者：Amos B. Smith ; III ; Wenyong Wang ; Adam K. Charnley ; Patrick J. Carroll ; Craig S. Kenesky ; Ralph Hirschmann
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 2, 2010
• 年：2010
• 卷：12
• 期：13
• 页码：2990-2993
• 全文大小：219K
• 年卷期：v.12,no.13(July 2, 2010)
• ISSN：1523-7052

文摘

To expand the potential conformational space available to the polypyrroline structural motif, an open chain, d,l-alternating hexapyrrolinone was designed and synthesized. Structural studies, including solution NMR and X-ray crystallographic analysis, revealed that the hexapyrrolinone adopts a turn conformation both in solution and in the solid state, with aggregation in solution and a nanotube-like quaternary structure in the crystal.