Design, Synthesis, and Structural Analysis of d,l-Mixed Polypyrrolinones. 2. Macrocyclic Hexapyrrolinones

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• 作者：Amos B. Smith ; III ; Hui Xiong ; Adam K. Charnley ; Meinrad Brenner ; Eugen F. Mesaros ; Craig S. Kenesky ; Luigi Di Costanzo ; David W. Christianson ; Ralph Hirschmann
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 2, 2010
• 年：2010
• 卷：12
• 期：13
• 页码：2994-2997
• 全文大小：229K
• 年卷期：v.12,no.13(July 2, 2010)
• ISSN：1523-7052

文摘

The design, synthesis, and structural analysis of two macrocyclic d,l-alternating hexapyrrolinones have been achieved. These cyclic peptide mimics adopt a flat, hexagonal conformation, stabilized by intramolecular hydrogen bonding between adjacent pyrrolinone rings. Extensive NMR studies and X-ray analysis reveal, respectively, that the macrocyclic hexapyrrolinones aggregate in solution and in the solid state form staggered stacked nanotube-like assemblies.