Acetylcholinesterase Inhibitors from the Leaves of Macaranga kurzii

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• 作者：Van Trinh Thi Thanh ; Huong Doan Thi Mai ; Van Cuong Pham ; Marc Litaudon ; Vincent Dumontet ; Fran莽oise Gu茅ritte ; Van Hung Nguyen ; Van Minh Chau
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：75
• 期：11
• 页码：2012-2015
• 全文大小：175K
• 年卷期：v.75,no.11(November 26, 2012)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A鈥揅, 2鈥?b>4). Nine known compounds were also isolated (5鈥?b>13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase inhibitory activity. Compound 6 (trans-3,5-dimethoxystilbene) exhibited the greatest activity (IC₅₀ 9 渭M). Cytotoxic evaluation against KB cells showed that compound 7 had an IC₅₀ of 4 渭M, followed by 11 (IC₅₀ 10 渭M) and 3 (IC₅₀ 13 渭M).