Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities
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- 作者：Chinmoy Pramanik ; Raghvendra R. Hivarekar ; Sanjay S. Deshmukh ; Narendra K. Tripathy ; Sandeep Kotharkar ; Ashok Chaudhari ; Mukund K. Gurjar
- 刊名：Organic Process Research & Development
- 出版年：2012
- 出版时间：May 18, 2012
- 年：2012
- 卷：16
- 期：5
- 页码：824-829
- 全文大小：286K
- 年卷期：v.16,no.5(May 18, 2012)
- ISSN：1520-586X
文摘
During process optimization of Escitalopram oxalate novel impurities, 6 and 7 were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved the yield and purity of the drug product during the bulk API synthesis.