Mercury(II) Recognition and Fluorescence Imaging in Vitro through a 3D-Complexation Structure

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• 作者：Mei-Lin Ho ; Kew-Yu Chen ; Gene-Hsiang Lee ; Yu-Chun Chen ; Chih-Chieh Wang ; Jyh-Fu Lee ; Wen-Chun Chung ; Pi-Tai Chou
• 刊名：Inorganic Chemistry
• 出版年：2009
• 出版时间：November 2, 2009
• 年：2009
• 卷：48
• 期：21
• 页码：10304-10311
• 全文大小：977K
• 年卷期：v.48,no.21(November 2, 2009)
• ISSN：1520-510X

文摘

8,8′-(1,4,10,13-Tetrathia-7,16-diazacyclooctadecane-7,16-diyl)-bis(methylene)diquinolin-7-ol (TTBQ) was synthesized and proved to selectively recognize Hg²⁺, forming a Hg²⁺/TTBQ complex with an association constant (K_a) as large as 1.3 × 10⁴ ± 520 M⁻¹ in aqueous solution. Single crystals of TTBQ and a TTBQ-Hg²⁺ complex have also been successfully grown, in which the latter unambiguously revealed a cagelike configuration consisting of thiol-crown and dual 7-hydroxyquinoline moieties to firmly trap Hg²⁺. This 3D-complexation structure accounts for 25-fold luminescence enhancement and a detection limit of sub-μM in water for sensing Hg²⁺. Great selectivity toward Hg²⁺ has been exhibited over alkali- and alkaline-earth metal ions, first-row transition-metal ions, and other cations studied. This chemosensor is particularly suited for the detection of Hg²⁺ in a pH range of 5.5 to 7.5. This, in combination with its fine biocompatibility, leads to the success toward in vitro mercury recognition based on fluorescence imaging.