Lycojaponicumins A鈥揅, Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum
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- 作者：Xiao-Jing Wang ; Gui-Jie Zhang ; Peng-Yu Zhuang ; Yan Zhang ; Shi-Shan Yu ; Xiu-Qi Bao ; Dan Zhang ; Yu-He Yuan ; Nai-Hong Chen ; Shuang-gang Ma ; Jing Qu ; Yong Li
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：May 18, 2012
- 年：2012
- 卷：14
- 期：10
- 页码：2614-2617
- 全文大小：242K
- 年卷期：v.14,no.10(May 18, 2012)
- ISSN：1523-7052
文摘
Lycojaponicumins A鈥揅 (1鈥?b>3), three trace alkaloids isolated from Lycopodium japonicum, represent a unique heterocyclic skeleton formed by the new linkage C4鈥揅9. Notably, lycojaponicumins A and B (1 and 2) are the first examples of natural products possessing a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These structures were elucidated by spectroscopic methods and X-ray diffraction analysis. A plausible biogenetic pathway was proposed.