Three New Indole Alkaloids from Trigonostemon lii

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• 作者：Cheng-Jian Tan ; Ying-Tong Di ; Yue-Hu Wang ; Yu Zhang ; Yi-Kang Si ; Qiang Zhang ; Suo Gao ; Xu-Jia Hu ; Xin Fang ; Shi-Fei Li ; Xiao-Jiang Hao
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2370-2373
• 全文大小：169K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

Three unprecedented indole alkaloids, trigonoliimines A−C (1−3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1−3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC₅₀ = 0.95 μg/mL, TI = 7.9).