Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats
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- 作者：Wei-Jan Huang ; Ho-Shan Niu ; Mei-Hsiang Lin ; Juei-Tang Cheng ; Fen-Lin Hsu
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：June 25, 2010
- 年：2010
- 卷：73
- 期：6
- 页码：1170-1172
- 全文大小：112K
- 年卷期：v.73,no.6(June 25, 2010)
- ISSN：1520-6025
文摘
The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase glycogen synthesis in STZ-diabetic rats. These results suggest that 1 can increase glucose utilization to lower plasma glucose in diabetic rats lacking insulin.