Radical Arylalkoxycarbonylation of 2-Isocyanobiphenyl with Carbazates: Dual C鈥揅 Bond Formation toward Phenanthridine-6-carboxylates

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• 作者：Changduo Pan ; Jie Han ; Honglin Zhang ; Chengjian Zhu
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：79
• 期：11
• 页码：5374-5378
• 全文大小：310K
• 年卷期：v.79,no.11(June 6, 2014)
• ISSN：1520-6904

文摘

A sequential oxidative radical alkoxycarbonylation and aromatization of 2-isocyanobiphenyl with carbazates was developed to furnish phenanthridine-6-carboxylates. Various functional groups such as methoxy, chloro, fluoro, trifluoromethoxy, and trifluoromethyl groups were tolerated well under the reaction conditions. The sequential radical addition鈥揷yclization strategy represents a practical route to access phenanthridine-6-carboxylates.