文摘
CuCl2-mediated intramolecular C鈥揌/C鈥揌 cross-dehydrogenative coupling (CDC) of thioalkyl-substituted 伪-acetyl or 伪-aroyl ketene N,S-acetals afforded 2-thioalkyl indoles. Tunable C鈥揝 bond transformations of the resultant indoles led to highly functionalized N-heterocyclic compounds. A 尾-thioalkyl is necessary to activate the N,S-acetal substrate and enable the CDC reaction to occur, and the relevant mechanism studies revealed that the CDC reaction follows a radical pathway.