Antidepressant Abietane Diterpenoids from Chinese Eaglewood

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• 作者：Lin Yang ; Lirui Qiao ; Chengxue Ji ; Dan Xie ; Ning-Bo Gong ; Yang Lu ; Jianjun Zhang ; Jungui Dai ; Shunxing Guo
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：February 22, 2013
• 年：2013
• 卷：76
• 期：2
• 页码：216-222
• 全文大小：313K
• 年卷期：v.76,no.2(February 22, 2013)
• ISSN：1520-6025

文摘

Ten new abietane diterpenoids, aquilarabietic acids A鈥揓 (1鈥?b>10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 渭M demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC₅₀ value of 9.1 脳 10^鈥? M.