Enantioselective Sequential Conjugate Addition−Allylation Reactions: A Concise Total Synthesis of (+)-Podophyllotoxin

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• 作者：Yingming Wu ; Jingfeng Zhao ; Jingbo Chen ; Chengxue Pan ; Liang Li ; Hongbin Zhang
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 5, 2009
• 年：2009
• 卷：11
• 期：3
• 页码：597-600
• 全文大小：210K
• 年卷期：v.11,no.3(February 5, 2009)
• ISSN：1523-7052

文摘

A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.