Reversibly Switching the Surface Porosity of a DNA Tetrahedron

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• 作者：Chuan Zhang ; Cheng Tian ; Xiang Li ; Hang Qian ; Chenhui Hao ; Wen Jiang ; Chengde Mao
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：July 25, 2012
• 年：2012
• 卷：134
• 期：29
• 页码：11998-12001
• 全文大小：273K
• 年卷期：v.134,no.29(July 25, 2012)
• ISSN：1520-5126

文摘

The ability to reversibly switch the surface porosity of nanocages would allow controllable matter transport in and out of the nanocages. This would be a desirable property for many technological applications, such as drug delivery. To achieve such capability, however, is challenging. Herein we report a strategy for reversibly changing the surface porosity of a self-assembled DNA nanocage (a DNA tetrahedron) that is based on DNA hydridization and strand displacement. The involved DNA nanostructures were thoroughly characterized by multiple techniques, including polyacrylamide gel electrophoresis, dynamic light scattering, atomic force microscopy, and cryogenic electron microscopy. This work may lead to the design and construction of stimuli-responsive nanocages that might find applications as smart materials.