Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin
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- 作者：Kai Cheng ; Sheng Peng ; Chenjie Xu ; Shouheng Sun
- 刊名：Journal of the American Chemical Society
- 出版年：2009
- 出版时间：August 5, 2009
- 年：2009
- 卷：131
- 期：30
- 页码：10637-10644
- 全文大小：316K
- 年卷期：v.131,no.30(August 5, 2009)
- ISSN：1520-5126
文摘
We report a new approach to cisplatin storage and release using porous hollow nanoparticles (PHNPs) of Fe3O4. We prepared the PHNPs by controlled oxidation of Fe NPs at 250 °C followed by acid etching. The opening pores (2−4 nm) facilitated the cisplatin diffusion into the cavity of the hollow structure. The porous shell was stable in neutral or basic physiological conditions, and cisplatin escape from the cavity through the same pores was a diffusion-controlled slow process with t1/2 = 16 h. However, in low pH (<6) conditions, the pores were subject to acidic etching, resulting in wider pore gaps and faster release of cisplatin with t1/2 < 4 h. Once coupled with Herceptin to the surface, the cisplatin-loaded hollow NPs could target to breast cancer SK-BR-3 cells with IC50 reaching 2.9 μM, much lower than 6.8 μM needed for free cisplatin. Our model experiments indicate that the low pH-responsive PHNPs of Fe3O4 can be exploited as a cisplatin delivery vehicle for target-specific therapeutic applications.