Dumbbell-like Au−Fe3O4 Nanoparticles for Target-Specific Platin Delivery

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• 作者：Chenjie Xu ; Baodui Wang^† ; ; Shouheng Sun*
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：April 1, 2009
• 年：2009
• 卷：131
• 期：12
• 页码：4216-4217
• 全文大小：147K
• 年卷期：v.131,no.12(April 1, 2009)
• ISSN：1520-5126

文摘

Dumbbell-like Au−Fe₃O₄ nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin−Au−Fe₃O₄−Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC₅₀) toward Sk-Br3 cells of 1.76 μg of Pt/mL, which is lower than that needed for cisplatin (3.5 μg/mL). The work demonstrates that the dumbbell-like Au−Fe₃O₄ NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.