ICl-Mediated Intramolecular Twofold Iodoarylation of Diynes and Diynyl Diethers and Amines: Synthesis of Bis(2H-hydronaphthalene and chromene) and 2H-Quinoline Bearing an Alkenyl Iodide
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- 作者：Juntae Mo ; Wonseok Choi ; Jiae Min ; Cheol-Eui Kim ; Dahan Eom ; Sung Hong Kim ; Phil Ho Lee
- 刊名：Journal of Organic Chemistry
- 出版年：2013
- 出版时间：November 15, 2013
- 年：2013
- 卷：78
- 期：22
- 页码：11382-11388
- 全文大小：385K
- 年卷期：v.78,no.22(November 15, 2013)
- ISSN：1520-6904
文摘
Electrophilic intramolecular twofold iodoarylation was developed from the reaction of diynes and diynyl diethers and amines with iodine monochloride under mild conditions, which produced bis(2H-hydronaphthalene and chromene) and 2H-quinoline bearing an alkenyl iodide moiety in good to excellent yields. These compounds underwent Pd-catalyzed cross-coupling reactions with arylboronic acid and indium tris(arylthiolate) to produce the functionalized styrene derivatives.