Automated In-line Technique Using FBRM to Achieve Consistent Product Quality in Cooling Crystallization

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• 作者：Jia Wei Chew ; Pui Shan Chow ; Reginald B. H. Tan
• 刊名：Crystal Growth & Design
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：7
• 期：8
• 页码：1416 - 1422
• 全文大小：333K
• 年卷期：v.7,no.8(August 2007)
• ISSN：1528-7505

文摘

An in-line technique involving focused beam reflectance measurement (FBRM) for control of crystal product qualityin unseeded systems is proposed. The method consists of nucleation detection followed by a holding time to internally generateseeds through primary nucleation and then controlled conditioning of these seeds using FBRM measurement of the particle sizedistribution (PSD). The technique has been successfully implemented for the cooling crystallization of glycine and paracetamol inwater. Results showed that the crystal product consistency using our technique was comparable to that of externally seededcrystallizations.