Comparison between Open-Loop Temperature Control and Closed-Loop Supersaturation Control for Cooling Crystallization of Glycine

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• 作者：Jia Wei Chew ; Simon N. Black ; Pui Shan Chow ; Reginald B. H. Tan
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2007
• 出版时间：January 31, 2007
• 年：2007
• 卷：46
• 期：3
• 页码：830 - 838
• 全文大小：428K
• 年卷期：v.46,no.3(January 31, 2007)
• ISSN：1520-5045

文摘

Consistent particle properties are an important goal for industrial batch crystallizations. Several control strategies,from unseeded linear cooling to seeded supersaturation control, were evaluated for the cooling crystallizationof glycine. Particle properties were assessed in-line, facilitating investigations of process consistency. Seedingwas by far the most effective strategy. Changing the preset cooling profile or the preset supersaturation limitshowed limited benefits. Crystal growth rates matched the rate of supersaturation increase for all coolingrates, so that seeded processes operated entirely within the metastable zone. No secondary nucleation wasobserved.