Antiallergic Asthma Properties of Brazilin through Inhibition of TH2 Responses in T Cells and in a Murine Model of Asthma
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- 作者：Chen-Chen Lee ; Chien-Neng Wang ; Jaw-Jou Kang ; Jiunn-Wang Liao ; Bor-Luen Chiang ; Hui-Chen Chen ; Chien-Ming Hu ; Chia-Der Lin ; Shih-Hsuan Huang ; Yu-Ting Lai
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：September 19, 2012
- 年：2012
- 卷：60
- 期：37
- 页码：9405-9414
- 全文大小：558K
- 年卷期：v.60,no.37(September 19, 2012)
- ISSN：1520-5118
文摘
This study aimed to determine whether brazilin exhibits anti-inflammatory effects that inhibit T helper cell type II (TH2) responses and whether it suppresses allergic inflammation reactions in a murine model of asthma. We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Following the intratracheal instillation of brazilin in ovalbumin (OVA)-immunized mice, we found that brazilin-treated mice exhibited decreases in the release of IL-4, IL-5, IL-13, eotaxin-1, and tumor necrosis factor-伪 in bronchoalveolar lavage fluid (BALF); inhibited TH2 functioning via a decrease in IL-4 production; and exhibited attenuation of OVA-induced lung eosinophilia, airway hyperresponsiveness, and airway remodeling. These results suggest that brazilin exhibits anti-TH2 effects both in vitro and in vivo and may possess therapeutic potential for allergic diseases.