Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from Hawaiian Palythoa Subspecies
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- 作者：Patrizia Ciminiello ; Carmela Dell’ ; Aversano ; Emma Dello Iacovo ; Ernesto Fattorusso ; Martino Forino ; Laura Grauso ; Luciana Tartaglione ; Chiara Florio ; Paola Lorenzon ; Marco De Bortoli ; Aurelia Tub
- 刊名：Chemical Research in Toxicology
- 出版年：2009
- 出版时间：November 16, 2009
- 年：2009
- 卷：22
- 期：11
- 页码：1851-1859
- 全文大小：274K
- 年卷期：v.22,no.11(November 16, 2009)
- ISSN：1520-5010
文摘
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography−mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.