Self-Assembly Behavior of Amphiphilic Poly(amidoamine) Dendrimers with a Shell of Aniline Pentamer

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• 作者：Wei-I Hung ; Chi-Hao Chang ; Ya-Han Chang ; Pei-Shan Wu ; Chih-Bing Hung ; Kung-Chin Chang ; Mei-Chun Lai ; Sheng-Chieh Hsu ; Yen Wei ; Xin-Ru Jia ; Jui-Ming Yeh
• 刊名：Langmuir
• 出版年：2013
• 出版时间：October 1, 2013
• 年：2013
• 卷：29
• 期：39
• 页码：12075-12083
• 全文大小：543K
• 年卷期：v.29,no.39(October 1, 2013)
• ISSN：1520-5827

文摘

A series of amphiphilic poly(amidoamine) dendrimers (PAMAM, G2鈥揋5) composed of a hydrophilic core and a hydrophobic shell of aniline pentamer (AP) were synthesized and characterized. The modified dendrimers self-assembled to vesicular aggregates in water with the critical aggregation concentration (CAC) decreased in the order of G2 > G3 > G4 > G5. It was found that the modified dendrimers self-organized into spherical aggregates with a bilayer vesicular structures and that the dendrimers in higher generation have more order structure, which may be attributed to the crystallization induced by the compacted effect of AP segments. In addition, larger spherical vesicles were observed under acidic and alkaline conditions, as compared with sizes of aggregates in neutral medium. At low pH, the tertiary amine groups of PAMAM-AP were transformed to ammonium salts; the polarons were formed from AP units by doping with strong acids, thereby leading to the stability of vesicular aggregates being better than that in double distilled water. Nevertheless, in high pH environment, the deprotonation of PAMAM-AP caused the enhancement of 蟺鈥撓€ interactions, resulting in generation of twins or multilayered vesicles.