Synthesis of Bioactive Speciosins G and P from Hexagonia speciosa

详细信息    查看全文

• 作者：Guillermo A. Guerrero-V谩squez ; Nuria Chinchilla ; Jos茅 M. G. Molinillo ; Francisco A. Mac铆as
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：September 26, 2014
• 年：2014
• 卷：77
• 期：9
• 页码：2029-2036
• 全文大小：411K
• ISSN：1520-6025

文摘

The first total synthesis of speciosins P and G, previously isolated from Hexagonia speciosa, is reported. These compounds have been synthesized by Sonogashira coupling from readily available starting materials. Siccayne was also synthesized from the same starting material in two steps along with a number of other derivatives. The compounds were tested in the wheat coleoptile bioassay. The most active compound was the intermediate 18, followed by 29 and 17. The structural requirements for activity in these compounds are the presence of methoxy groups in the aromatic ring and a formyl or hydroxy group in the side chain.