Dibenzocycloheptanoids from the Leaves of Cinnamomum subavenium
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- 作者：Hsiao-Ching Lin ; Shoei-Sheng Lee
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：October 26, 2012
- 年：2012
- 卷：75
- 期：10
- 页码：1735-1743
- 全文大小：349K
- 年卷期：v.75,no.10(October 26, 2012)
- ISSN：1520-6025
文摘
Five dibenzocycloheptatrienes (1鈥?b>3, 5, and 6) and one dibenzocycloheptadiene (8) together with 16 known compounds were isolated from the leaves of Cinnamomum subavenium. Application of HPLC-SPE-NMR to a selected fraction afforded two additional dibenzocycloheptatrienes (4, 7). The glycosides 2鈥?b>7 comprise two diastereomers because of the chiral glycosyl moiety and the axial chirality of the biphenyl system. Their structures were elucidated via ECD and 2D NMR analyses and chemical degradation. Subavenosides D (5) and E (6) showed moderate inhibitory activity against 伪-glucosidase type IV from Bacillus stearothermophilus with IC50 values of 50.7 and 19.0 渭M, respectively.