Ugi-4-Component Reaction Enabling Rapid Access to the Core Fragment of Massadine

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• 作者：Gary M. Chinigo ; Alexander Breder ; Erick M. Carreira
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：January 7, 2011
• 年：2011
• 卷：13
• 期：1
• 页码：78-81
• 全文大小：232K
• 年卷期：v.13,no.1(January 7, 2011)
• ISSN：1523-7052

文摘

A rapid method to access the densely functionalized core structure of massadine (1) has been developed. The use of the Ugi-4-component reaction involving a convertible isonitrile and an end-group differentiating ozonolysis constitute the key operations toward the synthesis of the D-ring subunit.