Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica

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• 作者：Jing-Jy Cheng ; Li-Jie Zhang ; Hui-Ling Cheng ; Chun-Tang Chiou ; I-Jung Lee ; Yao-Haur Kuo
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：October 22, 2010
• 年：2010
• 卷：73
• 期：10
• 页码：1655-1658
• 全文大小：141K
• 年卷期：v.73,no.10(October 22, 2010)
• ISSN：1520-6025

文摘

Six hexacyclic triterpene acids (1−6), named euscaphic acids A−F, and eight known triterpene acid compounds (7−14) were isolated from an ethanolic extract of twigs of Euscaphis japonica. Compounds 8 and 10 were isolated for the first time from a natural source. Triterpenes 1−6 possess hexacyclic skeletons with a 13α,27-cyclopropane ring. Structural elucidation of compounds 1−6 was established by spectroscopic methods, especially 2D NMR techniques (¹H−¹H COSY, HMQC, HMBC, and NOESY). Compounds 3, 4, and 14 showed significant cytotoxicity against different cancer cell lines [IC₅₀ = 2.54 (NCI-H460), 3.61 (MCF-7), and 3.27 μM (CEM) for 3, 4, and 14, respectively].