文摘
Six hexacyclic triterpene acids (1−6), named euscaphic acids A−F, and eight known triterpene acid compounds (7−14) were isolated from an ethanolic extract of twigs of Euscaphis japonica. Compounds 8 and 10 were isolated for the first time from a natural source. Triterpenes 1−6 possess hexacyclic skeletons with a 13α,27-cyclopropane ring. Structural elucidation of compounds 1−6 was established by spectroscopic methods, especially 2D NMR techniques (1H−1H COSY, HMQC, HMBC, and NOESY). Compounds 3, 4, and 14 showed significant cytotoxicity against different cancer cell lines [IC50 = 2.54 (NCI-H460), 3.61 (MCF-7), and 3.27 μM (CEM) for 3, 4, and 14, respectively].