Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

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• 作者：Jun-Ho Choi ; Dong-Wook Kim ; Nari Yun ; Jae-Sue Choi ; Md. Nurul Islam ; Yeong-Shik Kim ; Sun-Mee Lee
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1055-1060
• 全文大小：878K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

In this study, the hepatoprotective effects of hyperoside (1), a flavonoid glycoside isolated from Artemisia capillaris, have been examined against carbon tetrachloride (CCl₄)-induced liver injury. Mice were treated intraperitoneally with vehicle or 1 (50, 100, and 200 mg路kg^鈭?) 30 min before and 2 h after CCl₄ (20 渭L路kg^鈭?) injection. Levels of serum aminotransferases were increased 24 h after CCl₄ injection, and these increases were attenuated by 1. Histological analysis showed that 1 prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl₄ treatment, and these changes were reduced by administration of 1. Protein and mRNA expression of tumor necrosis factor-伪 (TNF-伪), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl₄ injection. Compound 1 suppressed TNF-伪, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that 1 has protective effects against CCl₄-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.