Solubility of Forms I and II of Clopidogrel Hydrogen Sulfate in Methanol and 2-Propanol Mixture

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• 作者：Won-Suk Choi ; Kwang-Joo Kim
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2011
• 出版时间：January 13, 2011
• 年：2011
• 卷：56
• 期：1
• 页码：43-47
• 全文大小：180K
• 年卷期：v.56,no.1(January 13, 2011)
• ISSN：1520-5134

文摘

The solubilities of forms I and II of clopidogrel hydrogen sulfate (CHS) in methanol + 2-propanol mixture were measured over the temperature range of (鈭? to +55) 掳C and the methanol mass fraction range of (1.0 to 0.1). Enthalpy and entropy of dissolution of forms I and II of CHS in methanol +2-propanol were determined by using the van鈥檛 Hoff equation. Form II had a lower solubility and a higher enthalpy of dissolution compared to those of form I, which indicated that form II was the stable form and form I was the metastable form at the studied temperature range of (鈭? to +55) 掳C.