文摘
Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding 鈥渉andle鈥?to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 105 M鈥?. The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions.