Cholinesterase-Responsive Supramolecular Vesicle

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• 作者：Dong-Sheng Guo ; Kui Wang ; Yi-Xuan Wang ; Yu Liu
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：June 20, 2012
• 年：2012
• 卷：134
• 期：24
• 页码：10244-10250
• 全文大小：473K
• 年卷期：v.134,no.24(June 20, 2012)
• ISSN：1520-5126

文摘

Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using 鈥渟uperamphiphiles鈥? provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer鈥檚 disease, and therefore, the present system may have potential for the delivery of Alzheimer鈥檚 disease drugs.