Chartarlactams A–P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities

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• 作者：Yong Li ; Chongming Wu ; Dong Liu ; Peter Proksch ; Peng Guo ; Wenhan Lin
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：138-147
• 全文大小：452K
• ISSN：1520-6025

文摘

Chemical examination of the solid culture of the endophytic fungus Stachybotrys chartarum isolated from the sponge Niphates recondita resulted in the isolation of 16 new phenylspirodrimanes, named chartarlactams A鈥揚 (1鈥?b>16), together with eight known analogues. Their structures were determined on the basis of extensive spectroscopic analysis, including X-ray single-crystal diffraction for the determination of the absolute configurations. The isoindolone-drimane dimer chartarlactam L (12) was determined as a new skeleton. Compounds 1鈥?b>6 and 8鈥?b>24 were evaluated for antihyperlipidemic effects in HepG2 cells, and the primary structure鈥揳ctivity relationships are discussed.