Isoflavone Dimers and Other Bioactive Constituents from the Figs of Ficus mucuso

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• 作者：Jean J. K. Bankeu ; Rustamova Khayala ; Bruno N. Lenta ; Dide虂rot T. Noungoue虂 ; Silve虁re A. Ngouela ; Sufyan A. Mustafa ; Khalid Asaad ; Mohammed I. Choudhary ; Sean T. Prigge ; Ralphreed Hasanov ; Augustin E. Nkengfack ; Etienne Tsamo ; Muhammad S. Ali
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：June 24, 2011
• 年：2011
• 卷：74
• 期：6
• 页码：1370-1378
• 全文大小：935K
• 年卷期：v.74,no.6(June 24, 2011)
• ISSN：1520-6025

文摘

Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A鈥揅 (1鈥?b>3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward 尾-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀ 0.68 渭M) showed inhibitory activity on 尾-glucuronidase enzyme, while 3 (IC₅₀ 7.69 渭M) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).