Carbon鈥揃oron Bond Cross-Coupling Reaction Catalyzed by 鈭扨Ph2 Containing Palladium鈥揑ndolylphosphine Complexes

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• 作者：Wing Kin Chow ; On Ying Yuen ; Chau Ming So ; Wing Tak Wong ; Fuk Yee Kwong
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：77
• 期：7
• 页码：3543-3548
• 全文大小：379K
• 年卷期：v.77,no.7(April 6, 2012)
• ISSN：1520-6904

文摘

This study describes the application of indolylphosphine ligands with a diphenylphosphino moiety to the palladium-catalyzed borylation of aryl chlorides. The combination of palladium metal precursor with PPh₂-Andole-phos, which comprises an inexpensive 鈭扨Ph₂ group, provides highly effective catalysts for the borylation of aryl chlorides. A range of functional groups such as 鈭扖N, 鈭扤O₂, 鈭扖HO, 鈭扖OMe, 鈭扖OOMe, and 鈭扖F₃ was compatible, and the catalyst loading down to 0.025 mol % of Pd can be achieved. The Pd/PPh₂-Andole-phos system is able to catalyze both borylation reaction and Suzuki鈥揗iyaura coupling reaction in a one-pot sequential manner for the direct synthesis of biaryl compounds in excellent yields.