Design of an Indolylphosphine Ligand for Reductive Elimination-Demanding Monoarylation of Acetone Using Aryl Chlorides

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• 作者：Wai Chung Fu ; Chau Ming So ; Wing Kin Chow ; On Ying Yuen ; Fuk Yee Kwong
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：17
• 期：18
• 页码：4612-4615
• 全文大小：364K
• ISSN：1523-7052

文摘

The rational design of a phosphine ligand for the reductive elimination-demanding Pd-catalyzed mono-伪-arylation of acetone is demonstrated and reported. The catalyst is tolerant of previously proven challenging electron-deficient aryl chlorides and provides excellent product yields with down to 0.1 mol % Pd. Preliminary investigations suggest that the rate-limiting step for the proposed system is the oxidative addition of aryl chlorides, in which it contradicts previous findings regarding the 伪-arylation of acetone with aryl halides.