文摘
Neurodegenerative diseases represent a challenge for biomedical research due to their high prevalence and lack of mechanism-based treatments. Because of the complex pathology of neurodegenerative disorders, multifunctional drugs have been increasingly recognized as potential treatments. We identified homobivalent 纬-carbolinium salts as potent inihitors of both cholinesterases, N-methyl-d-aspartate receptors, and monoamine oxidases. Homobivalent 纬-carbolines displayed similar structure鈥揳ctivity relationships on all tested targets and may present promising designed multiple ligands for the treatment of neurodegenerative disorders.