Efficient Nucleophilic Aromatic Substitution between Aryl Nitrofluorides and Alkynes

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• 作者：Patrick L. DeRoy ; Simon Surprenant ; Megan Bertrand-Laperle ; Christiane Yoakim
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：July 5, 2007
• 年：2007
• 卷：9
• 期：14
• 页码：2741 - 2743
• 全文大小：62K
• 年卷期：v.9,no.14(July 5, 2007)
• ISSN：1523-7052

文摘

The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promotedby sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mildconditions.