Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis

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• 作者：Yi-Ming Wang ; Jeffrey Wu ; Christina Hoong ; Vivek Rauniyar ; F. Dean Toste
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：August 8, 2012
• 年：2012
• 卷：134
• 期：31
• 页码：12928-12931
• 全文大小：303K
• 年卷期：v.134,no.31(August 8, 2012)
• ISSN：1520-5126

文摘

A chiral anion phase-transfer system for enantioselective halogenation is described. Highly insoluble, ionic reagents were developed as electrophilic bromine and iodine sources, and application of this system to o-anilidostyrenes afforded halogenated 4H-3,1-benzoxazines with excellent yield and enantioselectivity.