Efficient Dibenzo[c]acridine Helicene-like Synthesis and Resolution: Scaleup, Structural Control, and High Chiroptical Properties
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- 作者：Lo茂c Jierry ; Steven Harthong ; Christophe Aronica ; Jean-Christophe Mulatier ; Laure Guy ; St茅phan Guy
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：January 6, 2012
- 年：2012
- 卷：14
- 期：1
- 页码：288-291
- 全文大小：284K
- 年卷期：v.14,no.1(January 6, 2012)
- ISSN：1523-7052
文摘
Herein, we describe our recent expeditious synthesis of dibenzo[c]acridine helicene-like compounds on a large scale in pure enantiomeric form. This flexible synthesis allows for variation at several positions on the skeleton. Geometrical parameters related to these compounds have been obtained from monocrystal X-ray structure resolution. Additionally, chiroptical parameters have been recorded, highlighting the versatility of this family showing for example optical rotation at 589 nm varying between 135 and 150 deg g鈥?cm2.