A Highly Efficient Palladium/Copper Cocatalytic System for Direct Arylation of Heteroarenes: An Unexpected Effect of Cu(Xantphos)I

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• 作者：Jinkun Huang ; Johann Chan ; Ying Chen ; Christopher J. Borths ; Kyle D. Baucom ; Robert D. Larsen ; Margaret M. Faul
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：March 24, 2010
• 年：2010
• 卷：132
• 期：11
• 页码：3674-3675
• 全文大小：194K
• 年卷期：v.132,no.11(March 24, 2010)
• ISSN：1520-5126

文摘

Heteroarenes are important structural moieties in many chemical industry fields. A highly efficient Pd/Cu-catalyzed C−H arylation method for a range of heterocycles has been discovered. It was found that the key to the success of this transformation is a combination of a palladium catalyst and a well-defined copper cocatalyst. The efficiency and low loadings of catalyst (0.25 mol %) and cocatalyst (1 mol %) together with the mild reaction conditions demonstrate this method to be practically useful and mechanistically interesting.