Collaborative Total Synthesis: Routes to (±)-Hippolachnin A Enabled by Quadricyclane Cycloaddition and Late-Stage C–H Oxidation

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• 作者：Monica E. McCallum ; Christopher M. Rasik ; John L. Wood ; M. Kevin Brown
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：February 24, 2016
• 年：2016
• 卷：138
• 期：7
• 页码：2437-2442
• 全文大小：462K
• ISSN：1520-5126

文摘

Described herein are synthetic efforts toward the synthesis of hippolachnin A. Two independently devised routes from the Brown and Wood groups allowed for the synthesis of hippolachnin A from the unusual starting material, quadricyclane, by harnessing the power of late-stage C–H oxidation. Collaborative union of the best features of the two routes allowed for preparation of the molecule with improved efficiency.