Squish and CuAAC: Additive-Free Covalent Monolayers of Discrete Molecules in Seconds

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• 作者：Matthew A. Pellow ; T. Daniel P. Stack ; Christopher E. D. Chidsey
• 刊名：Langmuir
• 出版年：2013
• 出版时间：May 7, 2013
• 年：2013
• 卷：29
• 期：18
• 页码：5383-5387
• 全文大小：248K
• 年卷期：v.29,no.18(May 7, 2013)
• ISSN：1520-5827

文摘

A terminal alkyne is immobilized rapidly into a full monolayer by squishing a small volume of a solution of the alkyne between an azide-modified surface and a copper plate. The monolayer is covalently attached to the surface through a copper-catalyzed alkyne鈥揳zide cycloaddition (CuAAC) reaction, and the coverages of the immobilized electroactive alkyne species are quantified by cyclic voltammetry. A reaction time of less than 20 s is possible with no other reagents required. The procedure is effective under aerobic conditions using either an aqueous or aprotic organic solution of the alkyne (1鈥?00 mM).