Selective Cross-Coupling of (Hetero)aryl Halides with Ammonia To Produce Primary Arylamines using Pd-NHC Complexes

详细信息    查看全文

• 作者：Christopher Lombardi ; Jonathan Day ; Nalin Chandrasoma ; David Mitchell ; Michael J. Rodriguez ; Jennifer L. Farmer ; Michael G. Organ
• 刊名：Organometallics
• 出版年：2017
• 出版时间：January 23, 2017
• 年：2017
• 卷：36
• 期：2
• 页码：251-254
• 全文大小：335K
• ISSN：1520-6041

文摘

Herein we report the first example of (hetero)arylation of ammonia using a monoligated palladium-NHC complex. The new, rationally designed, precatalyst (DiMeIHept^Cl)Pd(allyl)Cl featuring highly branched alkyl chains has been shown to be effective in selective aminations across a range of challenging substrates, including nitrogen-containing heterocycles and those featuring base-sensitive functionality. The less bulky Pd-PEPPSI-IPent^Cl precatalyst performs well for ortho-substituted aryl halides, giving monoarylated products in high yield with good selectivity.