Engineering the Stem Cell Microenvironment
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- 作者：Christian M. Metallo ; Jeffrey C. Mohr ; Christopher J. Detzel ; Juan J. de Pablo ; Bernard J. Van Wie ; Sean P. Palecek
- 刊名：Biotechnology Progress
- 出版年：2007
- 出版时间：February 2007
- 年：2007
- 卷：23
- 期：1
- 页码：18 - 23
- 全文大小：244K
- 年卷期：v.23,no.1(February 2007)
- ISSN：1520-6033
文摘
Multipotent stem cells in the body facilitate tissue regeneration, growth, and wound healingthroughout life. The microenvironment in which they reside provides signals that direct theseprogenitors to proliferate, differentiate, or remain dormant; these factors include soluble molecules,the extracellular matrix, neighboring cells, and physical stimuli. Recent advances in the cultureof embryonic stem cells and adult progenitors necessitate an increased understanding of thesephenomena. Here, we summarize the interactions between stem cells and their local environment,drawing on in vivo observations and tissue culture studies. In addition, we describe novel methodsof characterizing the effects of various environmental factors and review new techniques thatenable scientists and engineers to more effectively direct stem cell fate.