Divergent Syntheses of Carbazole Alkaloids Clausenapin, Indizoline, Claulansine M, and Clausenaline D

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• 作者：Yizhen Liu ; Yanqin Guo ; Feixiang Ji ; Dong Gao ; Chuanjun Song ; Junbiao Chang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：81
• 期：10
• 页码：4310-4315
• 全文大小：353K
• 年卷期：0
• ISSN：1520-6904

文摘

We described the first total syntheses of clausenapin, indizoline, claulansine M, and a novel synthetic route to clausenaline D via divergent method. Key steps involved TFAA-mediated intramolecular acylation to construct the carbazole core and subsequent Claisen rearrangement to generate key intermediates for further elaboration to target molecules.