Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes

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• 作者：Da-Wei Huang ; Szu-Chuan Shen ; James Swi-Bea Wu
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：September 9, 2009
• 年：2009
• 卷：57
• 期：17
• 页码：7687-7692
• 全文大小：774K
• 年卷期：v.57,no.17(September 9, 2009)
• ISSN：1520-5118

文摘

Tumor necrosis factor-α was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.