Cytotoxic 5-Alkylresorcinol Metabolites from the Leaves of Grevillea robusta

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• 作者：Ta-Hsien Chuang ; Pei-Lin Wu
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：70
• 期：2
• 页码：319 - 323
• 全文大小：82K
• 年卷期：v.70,no.2(February 2007)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of the MeOH extract of the leaves of Grevillea robusta led to the isolation of six new5-alkylresorcinols, gravicycle (1), dehydrogravicycle (2), bisgravillol (3), dehydrobisgravillol (4), dehydrograviphane(5), and methyldehydrograviphane (6), as well as eight known compounds. The structures of these compounds weredetermined by spectroscopic and chemical methods. Graviphane (7) and methylgraviphane (8) were isolated in the pureform for the first time from a natural source. The compounds all showed marginal cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines.