Synthesis of the South Unit of Cephalostatin. 7. Total Syntheses of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K
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- 作者：Jae Uk Jeong ; Chuangxing Guo ; and P. L. Fuchs
- 刊名：Journal of the American Chemical Society
- 出版年：1999
- 出版时间：March 17, 1999
- 年：1999
- 卷：121
- 期：10
- 页码：2071 - 2084
- 全文大小：761K
- 年卷期：v.121,no.10(March 17, 1999)
- ISSN：1520-5126
文摘
Transformation of alcohol 4 to 
-azidoketone 6, a hexacyclic steroid bearing the requisite functionalityand spiroketal stereochemistry of the symchiral South portion of cephalostatin 7 (10) is described. Reaction ofa 1:1 mixture of -azidoketones 5 and 6 with sodium hydrogen telluride is followed by cleavage of the protectinggroups cephalostatin 12 (9), cephalostatin 7 (10), and ritterazine K (11).
-azidoketone 6, a hexacyclic steroid bearing the requisite functionalityand spiroketal stereochemistry of the symchiral South portion of cephalostatin 7 (10) is described. Reaction ofa 1:1 mixture of -azidoketones 5 and 6 with sodium hydrogen telluride is followed by cleavage of the protectinggroups cephalostatin 12 (9), cephalostatin 7 (10), and ritterazine K (11).