Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo
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- 作者：Nei-Chi Liu ; Pei-Fang Hsieh ; Ming-Kun Hsieh ; Zih-Ming Zeng ; Hsiao-Ling Cheng ; Jiunn-Wang Liao ; Pin Ju Chueh
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：March 14, 2012
- 年：2012
- 卷：60
- 期：10
- 页码：2758-2765
- 全文大小：368K
- 年卷期：v.60,no.10(March 14, 2012)
- ISSN：1520-5118
文摘
Cancer chemoprevention is employed to block or reverse the progression of malignancies. To date, several thousands of agents have been found to possess chemopreventative activity, one of which is capsaicin, a component of chili peppers that exhibits antigrowth activity against various cancer cell lines. However, the role of capsaicin in tumorigenesis remains controversial because both cancer prevention and promotion have been proposed. Here, we made the unexpected discovery that treatment with low concentrations of capsaicin up-regulates tNOX (tumor-associated NADH oxidase) expression in HCT116 human colon carcinoma cells in association with enhanced cell proliferation and migration, as evidenced by down-regulation of epithelial markers and up-regulation of mesenchymal markers. Importantly, tNOX-knockdown in HCT116 cells by RNA interference reversed capsaicin-induced cell proliferation and migration in vitro and decreased tumor growth in vivo. Collectively, these findings provide a basis for explaining the tumor-promoting effect of capsaicin and might imply that caution should be taken when using capsaicin as a chemopreventive agent.