Peniciketals A–C, New Spiroketals from Saline Soil Derived Penicillium raistrichii

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• 作者：Wei-Zhong Liu ; Li-Ying Ma ; De-Sheng Liu ; Yu-Ling Huang ; Chun-Hua Wang ; Shou-Sen Shi ; Xiao-Hong Pan ; Xiao-Dong Song ; Rong-Xiu Zhu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 3, 2014
• 年：2014
• 卷：16
• 期：1
• 页码：90-93
• 全文大小：266K
• ISSN：1523-7052

文摘

Peniciketals A鈥揅 (1鈥?b>3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii. Their structures including absolute configurations were established by NMR, X-ray diffraction, and ECD calculations. Their cytotoxicities were tested against A549, HL-60, and K562 cell lines, and 1鈥?b>3 showed the selective effects on HL-60 cells with IC₅₀ values of 3.2, 6.7, and 4.5 渭M, respectively.