文摘
A rhodium/diene complex catalyzed asymmetric 1,4-addition of arylboronic acids to indole-derived α,β-unsaturated esters to access highly enantioenriched 3-(1<i>Hi>-indol-2-yl)-3-arylpropanoates has been developed. By taking advantage of the nucleophilic character of indole at C3 and N1 positions, construction of a series of valuable chiral tricyclic indole frameworks such as 2,3-dihydro-1<i>Hi>-pyrrolo[1,2-<i>ai>]indoles and cyclopenta[<i>bi>]indoles can be efficiently achieved.