Cytotoxic Psammaplysin Analogues from a Suberea sp. Marine Sponge and the Role of the Spirooxepinisoxazoline in Their Activity

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• 作者：Yeon-Ju Lee ; Saem Han ; Hyi-Seung Lee ; Jong Soon Kang ; Jieun Yun ; Chung J. Sim ; Hee Jae Shin ; Jong Seok Lee
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1731-1736
• 全文大小：261K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from a Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives (10鈥?b>13), and the other four were ceratinamine derivatives (14鈥?b>17). Of the compounds obtained, the psammaplysins exhibited cytotoxicity against human cancer cell lines (GI₅₀ values down to 0.8 渭M), while the ceratinamine and moloka鈥檌amine analogues showed almost no activity. These results suggest that the spirooxepinisoxazoline ring system is a requirement for cytotoxicity and, therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.